Prevention and Treatment of Toxoplasmosis
In the case of toxoplasmosis prevention is a matter of hygiene, washing hands after handling raw meat to avoid cat feces during yardwork or gardening. Cooking meat at a temperature of at least 66°C or frozen at - 20°C. Keep food from being contaminated by animals or insects home. First trimester pregnant women should be checked regularly in the possibility of infection with Toxoplasma gondii. Treat to prevent miscarriage, stillbirth, or congenital defects.
Until now, the best treatment is a combination of pyrimethamine with trisulfapyrimidine. The combination of the two drugs would synergistically inhibit the cycle p-amino benzoic acid and folic acid cycle. The recommended dose for pyrimethamine is 25-50 mg per day for a month and trisulfapyrimidine dose 2000-6000 mg a day for a month.
Because the side effects of these drugs are leukopenia and thrombocytopenia, it is recommended to add folic acid and yeast during treatment. Trimetoprinm also proved to be effective for the treatment of toxoplasmosis but when compared with the combination of pyrimethamine and trisulfapyrimidine, trimethoprim apparently still losing effectiveness.
Spiramycin is the drug of choice although less effective but less side effects when compared to previous medications. The recommended dose of spiramycin is 2-4 grams a day divided into 2 or 4 feedings. Some researchers advocate the treatment of first-trimester pregnant women with spiramycin 2-3 grams a day for a week or 3 weeks later followed by 2 weeks without medication. Such alternate until healed. Treatment is also aimed at patients with clear clinical symptoms and the infants born to mothers with toxoplasmosis.
Categories:
diseases,
pregnancy,
toxoplasma
0 comments:
Post a Comment